Matty, a successful actor, relocates to Miami to propose to his girlfriend, Annie. After a confrontation about her abortion, he spirals into a drug-fueled night with his friend Mickey (Dennis Hopper). The following morning, he wakes up with no recollection of the events, including a mysterious woman named Annie 2 (Sarah Lassez). Eighteen months later, sober and attending Alcoholics Anonymous meetings, Matty returns to Miami to uncover the truth about that night and the fate of Annie 1 (Béatrice Dalle), leading him to confront unsettling truths about himself.