The movie centers around Catherine Deane (played by Jennifer Lopez), a child psychologist who uses an experimental technology that allows her to enter the minds of her patients.

When a serial killer named Carl Stargher (played by Vincent D'Onofrio) falls into a coma just before his latest victim can be found, FBI agent Peter Novak (played by Vince Vaughn) enlists Catherine's help to enter Stargher’s mind and find the location of the kidnapped woman before it's too late.

Inside his twisted psyche, Catherine navigates nightmarish dreamscapes shaped by Carl’s trauma and psychosis, facing surreal dangers and dark secrets.